Dynamic Grade of Student how JS

I have a question, I need to make a school bulletin in js, imagining that each column of a table, modifying a student's note and calculations are done automatically through a parameterized formula, today I have an application with a table and when is changed "blur" column "" runs an ajax, the performance of this is awful, would you like your opinion of which technology would be better in this case? is a system that used around 50 thousand people a day, using this grade, I was thinking of using React or KnockoutJs that I know has observables to read the formula, which technology you would use for such a dynamic table. Every help is welcome.